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November 16, 2014
Why are so few blockbuster drugs invented today?
March 26, 2012
Findings from Cornell University College of Medicine in HIV/AIDS Reported
Investigators discuss in "a(1)Proteinase Inhibitor Regulates CD4 Lymphocyte Levels and Is Rate Limiting in HIV-1 Disease" new findings in HIV/AIDS. According to the authors of recent research from New York City, New York, "The regulation of adult stem cell migration through human hematopoietic tissue involves the chemokine CXCL12 (SDF-1) and its receptor CXCR4 (CD184). In addition, human leukocyte elastase (HLE) plays a key role." "When HLE is located on the cell surface (HLE(CS)), it acts not as a proteinase, but as a receptor for a(1)proteinase inhibitor (a(1)PI, a(1)antitrypsin, SerpinA1). Binding of a(1)PI to HLE(CS) forms a motogenic complex. We previously demonstrated that a(1)PI deficiency attends HIV-1 disease and that a(1)PI augmentation produces increased numbers of immunocompetent circulating CD4(+) lymphocytes," wrote C.L. Bristow and colleagues, Cornell University College of Medicine.
February 2, 2004
Human leukocyte elastase can act as HIV coreceptor
According to recent research from New York, HLE "interacts with HIV-1 glycoprotein (gp)41, suggesting a nonenzymatic receptor function for HLE in the context of HIV-1." "HLE is found localized to the cell surface, but not granules in HIV permissive clones, and to granules, but not the cell surface of HIV nonpermissive clones," noted C.L. Bristow and coauthors at Rockefeller University.